Saji soman biography of abraham graham

Media releases Our stories Media coverage Publications Our magazine. We have also unraveled novel intracellular innate host defense activities including expulsion of whole bacteria from infected epithelial cells, a feat mediated by immune recognition molecules and the cellular trafficking system. Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG.

Browser not supported Modern websites need modern browsers To enjoy the full experience, please upgrade your browser Try this browser. We have also unraveled novel intracellular innate host defense activities including expulsion of whole bacteria from infected epithelial cells, a feat mediated by immune recognition molecules and the cellular trafficking system.

The second area of research investigates cross-talk between distinct infectious agents such as Uropathogenic E. We believe that there is a significant amount of crosstalk occurring between bacteria and host cells during infection and that the outcome of this interaction dictates both how quickly the infection is cleared and the severity of the pathology associated with the infection.

We also believe that through deciphering this crosstalk we should be able to selectively promote certain beneficial interactions while abrogating the harmful ones. Host-pathogen crosstalk, Role of Mast cell in modulating innate and adaptive immune responses, Vaccine development against emerging infectious agents, Urinary tract infections and the development of novel strategies to combat these infections.

Our current investigations are centered on elucidating the molecular and cellular aspects of how mast cells mediate their immunomodulatory role. The Abraham laboratory is interested in developing innovative approaches for curbing microbial infections through the study of the molecular interactions occurring between pathogenic bacteria and prominent immune and epithelial cells.

Governing Board Senior Management. Our current investigations are centered on elucidating the molecular and cellular aspects of how mast cells mediate their immunomodulatory role.

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Research Interests Host-pathogen crosstalk, Role of Mast cell in modulating innate and adaptive immune responses, Vaccine development against emerging infectious agents, Urinary tract infections and the development of novel strategies to combat these infections. The first involves elucidating the role of mast cells in modulating immune responses to microbes.

Postdoctoral Fellowship University of Tennessee, Knoxville. Our studies have revealed that mast cells play a key sentinel role and upon bacterial or viral infection, modulate both innate and adaptive immune responses through the release of immunomodulatory molecules borne in granules. There are two major research areas being pursued in this laboratory.

Mast cell-sensory neuron crosstalk in allergic diseases. Quick links:. We are also examining several mast cell-targeted strategies to boost immunity to infections as well as reduce any pathological consequences of infection. Our studies have revealed that mast cells play a key sentinel role and upon bacterial or viral infection, modulate both innate and adaptive immune responses through the release of immunomodulatory molecules borne in granules.

We believe that there is a significant amount of crosstalk occurring between bacteria and host cells during infection and that the outcome of this interaction dictates both how quickly the infection is cleared and the severity of the pathology associated with the infection.

Twists and Turns: Soman Abraham, PhD - Issuu

The second area of research investigates cross-talk between distinct infectious agents such as Uropathogenic E. For our researchers For collaborators For aspiring innovators and learners. Why Duke-NUS? Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components. Bio The Abraham laboratory is interested in developing innovative approaches for curbing microbial infections through the study of the molecular interactions occurring between pathogenic bacteria and prominent immune and epithelial cells.